Endocrine Abstracts

Growth hormone (GH) acts chronically to decrease adiposity, at least in part by the inhibition of lipogenesis. One or more of the twelve isoforms of Protein kinase C (PKC) may be involved in this chronic effect of GH on lipogenesis in adipocytes.Two approaches were adopted to examine the role of PKC isoforms in GH signalling. The first method involved maintaining explants of Finn/Dorset sheep adipose tissue with insulin, GH or a combination of both, for ...

Case history: A 38-year-old man was referred with a 12-month history of recurrent bouts of transient hyponatraemia (serum sodium ranging from 115 to 125 mmol/l). Citalopram, which he was taking for depression, was discontinued, but the episodes continued.Initial investigations: Whilst symptomatic, and clinically euvolaemic, his biochemical profile was consistent with a syndrome of inappropriate antidiuresis (SIAD): sodium 124 mmol/l, potassium 4.5 mmol/l...